I know I am going against the grain, but I think the Saints will win. I think they are going to out shoot Manning. IMO Mannings receivers are a little too young for this stage. Wayne and Clark may move the offense for Manning, but I don't think it will be enough to keep up with the Saints. Neither defense is really any good, so that is a draw and the Saints CAN run the ball, while the Colts running game is basically short passes.
I guess I am just more impressed with the Saints than the Colts. The Colts can't run, or stop the run, that is a big no no at this point, IMO.