10 receivers? So the center is eligible? Are the tight ends not covered up by any of the wide outs?
If a team planned on running this full-time, defenses would need to change their recruiting/lineup and put FAST (no longer huge) guys in every position. Leave the center alone, cover the 9 potential receivers, and have two of your fastest-off -the-line guys to play D-end/OLB and rush the passer every single play. Have the guys that are covering the tight ends line up tight on them so they can't block the rushers. The extra QB can only pick up one of them and the center won't have a chance to get back in time. All receivers have a man on them and the QB won't have time for anything more than a two-step drop. The ball is going to see a lot of dirt and/or the QB will be getting punished often.
I guess if they mix it up a lot and don't show what they're doing until they come out of the huddle, you could definitely catch the D off guard.
I don't see any NFL (or even college level) teams running this offense a whole lot. Maybe some variant of two QBs, but not without some kind of pass protection.